Fentanycin has been gradually introduced to the market in Europe, America, and some countries, and has been gradually included in the standard treatment guidelines for Clostridium difficile infections. Foreign news has reported that the recurrence rate of non fungicide in clinical trials is significantly lower than that of vancomycin, providing a new treatment option for patients with refractory and recurrent Clostridium difficile infections.

1、 Drug name

1. Common name: Fidaxomicin

2. Product Name: Dificid

2、 Indications

Used to treat Clostridium difficile associated diarrhea (CDAD) in adults and children aged 6 months and above. Only applicable to confirmed or highly suspected infections caused by Clostridium difficile to reduce the development of drug-resistant bacteria.

3、 Specifications and characteristics

Tablets: 200mg

4、 Main components

Active ingredient: Non dauricin sesquihydrate. Auxiliary materials include microcrystalline cellulose, citric acid, mixed berry essence, etc. (suspension) or magnesium stearate, polyvinyl alcohol, etc. (tablet).

5、 Usage and dosage

1. Adults: 200mg tablets taken orally twice a day for a course of 10 days.

2. Children:

(1) For those weighing ≥ 12.5kg and able to swallow tablets: 200mg tablets twice a day.

(2) For those weighing ≥ 4kg: use suspension according to body weight (e.g. 80mg/time for 4-7kg, 120mg/time for 7-9kg).

3. Usage: Can be taken with food or on an empty stomach. If there is a delay of at least 12 hours from the next administration when missed, it can be supplemented.

6、 Dose adjustment

1. Blood toxicity: Suspend administration when hemoglobin<8g/dL or platelet<100000/mcL, and reduce to 100mg/dose after recovery.

2. Hepatotoxicity: Permanently discontinue medication when ALT/AST>5 times normal or bilirubin>3 times normal.

7、 Medication precautions

1. Monitoring requirements: Regular testing of liver function, blood routine, and electrolytes during treatment.

2. Allergic reactions: Immediate discontinuation of medication is required for symptoms such as difficulty breathing and vascular edema.

8、 Medication for special populations

1. Pregnant women: There is no sufficient data yet, so it is necessary to weigh the pros and cons.

2. Breastfeeding period: Suspend breastfeeding or medication.

3. Children: Safety has not been established for children under 6 months old.

4. Elderly: No need to adjust dosage.

9、 Adverse reactions

1. Common in adults: nausea (11%), vomiting (7%), abdominal pain (6%), gastrointestinal bleeding (4%).

2. Common in children: fever (13%), abdominal pain (8%), rash (5%).

10、 Contraindications

Prohibited for individuals allergic to non dauricin or excipients.

11、 Drug interactions

1. Combined use with cyclosporine may increase the blood concentration of non fungicide, but there is no need to adjust the dosage.

2. Avoid combination with potent P-glycoprotein inhibitors.

12、 Storage method

Tablets: Store at room temperature of 20-25 ° C.

Dificidinformation