The daily dosage of Lorlatinib should be determined based on the patient's condition and tolerance. The standard dosage is 100mg orally once a day, and the specific number of tablets should be calculated according to the drug specifications. If adverse reactions occur or the dosage needs to be adjusted for special populations, medical advice should be strictly followed.

Calculation of standard dose and number of tablets

(1) Conventional dose: 100mg orally each time, once daily, continue treatment until disease progression or intolerable toxicity.

(2) Reference for number of tablets: If the drug specification is 100mg/tablet, take 1 tablet daily; If it is 25mg/tablet, then 4 tablets are required.

2 dose adjustment plan

(1) First dose reduction: Reduce to 75mg/day when adverse reactions occur (e.g. 3/4 tablets or change specifications for 100mg tablets).

(2) Secondary reduction: If still intolerant, it can be reduced to 50mg/day (half a tablet is required for 100mg tablets).

3. Dose adjustment for special populations

(1) Renal insufficiency: Severe impairment (creatinine clearance rate 15-30mL/min) should be reduced to 75mg/day.

(2) Liver dysfunction: mild damage does not require adjustment; Moderate to severe lack of data requires careful evaluation.

4 Medication precautions

(1) Whole piece ingestion: Do not cut or chew, high-fat diet does not affect absorption.

(2) Omission treatment: If it is close to the next administration time, it should be skipped rather than supplemented.