The daily dosage of Lorlatinib depends on the drug specifications and individual patient conditions. The standard dose is 100mg/day, and the specific number of pills needs to be calculated based on the specifications. If dosage adjustment is necessary, strict adherence to the reduction plan for adverse reactions or special populations should be followed.

Conversion between standard dose and particle count

(1) Basic plan: Take 100mg orally once a day and continue treatment until disease progression or intolerable toxicity occurs.

(2) Calculation of number of pills: If it is 100mg/pill, take 1 pill per day; 50mg/capsule requires 2 capsules; 25mg/capsule requires 4 capsules.

2. Dose adjustment for adverse reactions

(1) First reduction: Reduce to 75mg/day (if 100mg/pill, 3/4 pills are required or switch to a combination of 50mg+25mg).

(2) Secondary dose reduction: 50mg/day (half a pill for 100mg/pill or 2 pills for 25mg/pill), discontinue if intolerant.

3. Medication adjustments for special populations

(1) Renal insufficiency: Severe patients (creatinine clearance rate 15-30mL/min) need to reduce to 75mg/day.

(2) Liver dysfunction: Mild without adjustment, moderate to severe lack of data requires individualized evaluation.

4 Key Medication Tips

(1) Whole pill ingestion: Do not break or chew, eating does not affect absorption.

(2) Omission handling: Skip near the next administration time to avoid double dose supplementation.