Esomeprazole is a proton pump inhibitor mainly used for the treatment of acid related diseases such as gastroesophageal reflux disease and peptic ulcers. Its usage and dosage need to be adjusted according to the indications. Special attention should be paid to pregnant, lactating, and patients with liver and kidney dysfunction when using it for special populations. The following provides detailed instructions on usage, dosage, and medication for special populations.

1. Usage and dosage

(1) Gastroesophageal reflux disease: The recommended dose is 20mg once a day, with a treatment period of 4-8 weeks. Maintenance therapy can be administered with 20mg once daily or as needed.

(2) Peptic ulcer: For duodenal ulcer, 20mg is recommended once a day for a 4-week treatment course; For gastric ulcers, it is recommended to take 20-40mg once a day for a course of 8 weeks.

(3) Helicobacter pylori eradication: in combination with antibiotics, 20mg twice daily is recommended for a course of 7-10 days.

(4) Zhuo Ai syndrome: The initial dose is 40mg twice a day, adjusted according to symptoms, and the maximum dose does not exceed 120mg per day.

2. Medication for special populations

(1) Pregnancy: Animal experiments have not shown direct reproductive toxicity, but human data is limited, and pregnancy should only be used when explicitly necessary.

(2) Breastfeeding period: Esomeprazole can be secreted into breast milk. Breastfeeding women should weigh the pros and cons and suspend breastfeeding if necessary.

(3) Children: Adult doses are available for children over 12 years old, but safety has not been established for children under 12 years old.

(4) Elderly: No need to adjust dosage, but attention should be paid to possible liver and kidney dysfunction.

(5) Liver dysfunction: For severe liver dysfunction, the daily dose should not exceed 20mg.

(6) Renal insufficiency: No dosage adjustment is required, but caution should be exercised in patients with end-stage renal disease.