Esomeprazole is a proton pump inhibitor (PPI) that irreversibly blocks the final step of gastric acid secretion by specifically inhibiting the H+/K+ATPase system on the secretion surface of gastric wall cells.

1、 Drug name

1. Common name: Esomeprazole

2. Product Name: NEXIUM ®

2、 Indications

1. Adults and adolescents aged 12-17:

Short term treatment for erosive esophagitis (EE) in adults and patients aged 12-17 years.

Maintenance treatment for adult EE after healing.

Short term treatment for symptoms of gastroesophageal reflux disease (GERD).

Reduce the risk of gastric ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for patients aged 60 and above or with a history of gastric ulcers.

Combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori (H. pylori) and reduce the risk of recurrent duodenal ulcers in adults.

Long term treatment for pathological overproduction, including Zollinger Ellison syndrome.

2. Children aged 1-11:

NEXIU oral suspension is used for short-term treatment of EE.

Used for short-term treatment of GERD symptoms.

3. Infants and young children aged 1 month to less than 1 year old:

NEXIU oral suspension is used for short-term treatment of EE caused by acid mediated GERD.

Note: NEXIUD is not recommended for the treatment of symptomatic GERD in infants aged 1 month to less than 1 year, as its efficacy has not been confirmed.

3、 Specifications and characteristics

Esomeprazole Magnesium Delayed Release Capsules: 40mg.

4、 Main components

Active ingredient: esomeprazole magnesium trihydrate

5、 Usage and dosage

1. Recommended route of administration:

Capsules: taken orally or administered through a nasogastric tube.

Recommended administration time: Take at least one hour before meals.

Combination with antacids: Can be used simultaneously with antacids.

6、 Dose adjustment

1. Patients with liver dysfunction:

Severe liver injury (Child Pugh C grade): The recommended maximum dose is 20mg once daily (for EE healing, reducing the risk of NSAID related gastric ulcers, eradicating H. pylori, and pathological overproduction).

7、 Medication precautions

1. Related to food: It should be taken at least 1 hour before meals.

2. Missing server treatment: Please remember and replace it as soon as possible. If it is close to the next medication time, skip the missed dose and take the next dose at the regular time. Do not take twice the dose at once.

3. Vomiting treatment: No special instructions; If it is serious, you should consult a doctor or pharmacist.

4. Other precautions: must be swallowed whole; Do not chew or crush. Do not chew or crush the particles.

8、 Medication for special populations

1. Children: EE and GERD have been approved for use in children of different age groups. The efficacy of symptomatic GERD in infants aged 1 month to 1 year has not been confirmed and is not recommended for use.

2. Older adults: usually do not require dose adjustment, but individual sensitivity may increase.

3. Pregnant women: available, but with potential risks (animal data shows embryo/fetal toxicity and bone morphology changes). Be cautious and weigh the pros and cons.

4. Breastfeeding period: Available, but breast milk may contain drugs, the pros and cons should be weighed.

9、 Adverse reactions

1. Common adverse reactions (incidence ≥ 1%):

Adults: headache, diarrhea, nausea, bloating, abdominal pain, constipation, dry mouth.

Children (1 to 17 years old): Headache, diarrhea, abdominal pain, nausea, drowsiness.

Infants and young children (1 month to less than 1 year old): abdominal pain, vomiting, shortness of breath, elevated ALT levels.

10、 Contraindications

1. Known to be allergic to any ingredients that replace benzimidazole drugs or NEXIUM.

2. Used in conjunction with products containing riptyline (such as for treating HIV-1).

3. Child taboos: Unclear, usually follow medical advice.

11、 Drug interactions

1. Combination use must be avoided: products containing rilipiline, clopidogrel, St. John's wort, and rifampicin.

2. Dosage adjustment or monitoring is required: warfarin, methotrexate, cilostazol, digoxin, etc.

12、 Storage method

1. Temperature: Store at room temperature (25 ° C), with a permissible fluctuation range of 15 ° C to 30 ° C (59 ° F to 86 ° F).

2. Other: Keep the container of NEXIUM capsules tightly closed. If divided, please use sealed containers.

Esomeprazoleinformation