The contraindications for perfluorohexane octane eye drops (Miebo) involve individuals with special physiological conditions and allergies, and their usage restrictions must be strictly followed when interacting with specific foods. The following provides a detailed explanation from three aspects: taboo groups, taboo foods, and usage restrictions.

1. Taboo population

(1) Allergic constitution: Individuals with a history of hypersensitivity reactions to perfluorocarbons or excipients in formulations (such as medium chain triglycerides) are contraindicated.

(2) Acute eye infection: Active bacterial/viral conjunctivitis and keratitis patients should avoid using it, as it may interfere with infection control.

(3) Severe corneal injury: Do not use when there is a large area of corneal epithelial defect or ulcer, which may delay the healing process.

2. Forbidden foods

(1) High fat diet: Taking medication within 1 hour after consuming meals with a fat content greater than 30g may reduce the corneal adsorption rate of the medication.

(2) Alcoholic beverages: Ethanol intake>20g/day may enhance eye irritation, and it is recommended to limit alcohol consumption during medication.

3. Usage restrictions

(1) Special physiological state

Pregnancy: Animal experiments have not shown teratogenicity, but human data is insufficient. It is recommended to use only when potential benefits outweigh risks.

Breastfeeding period: It is unknown whether breast milk is secreted. As a precautionary measure, it is recommended to suspend breastfeeding during medication.

(2) Age restrictions

Children: The safety and efficacy of patients under 18 years old have not been established and should be used under strict supervision of an ophthalmologist.

Elderly: Patients aged 65 and above do not need to adjust the dosage, but need to monitor corneal tolerance more frequently.

(3) Other restrictions

Driving operation: Short term blurred vision may occur after medication, it is recommended to avoid driving or operating precision instruments for 15 minutes.

Contact lenses: Wait for 30 minutes after administration before wearing to avoid lens material denaturation.