The medication precautions for Revuforj involve dose adjustment, adverse reaction monitoring, contraindications, and special medication situations, which must be strictly followed to ensure treatment safety and effectiveness. The following content provides detailed explanations based on drug characteristics and clinical usage standards.

Dosage and administration plan

The standard dose of remifentanil should be adjusted according to the patient's weight and liver function. During the treatment period, it is necessary to regularly evaluate the efficacy and tolerability, and consider reducing or suspending medication when adverse reactions occur. If missed, the original dose should be taken at the next administration time, and double dose supplementation is prohibited.

2. Key points of adverse reaction monitoring

It is necessary to closely monitor liver function indicators, check every 2 weeks during the initial stage of treatment, and recheck monthly after stabilization. Pay attention to possible symptoms of interstitial lung disease, such as difficulty breathing, worsening cough, etc. Neurological symptoms such as dizziness and ataxia also need to be evaluated in a timely manner.

3 Contraindications and Use with Caution

Patients with severe liver dysfunction are prohibited from using it. Prohibited during pregnancy, women of childbearing age should take effective contraceptive measures until a specific time after discontinuing the medication. Individuals with a history of QT interval prolongation or using other QT prolonging drugs should use with caution.

4 Drug Interactions

Avoid using in combination with potent CYP3A4 inhibitors or inducers. Co administration with anticoagulants may increase the risk of bleeding, and close monitoring of coagulation function is necessary. Proton pump inhibitors may reduce drug absorption, and it is recommended to administer them intermittently.

Medication for 5 special populations

Elderly patients do not need to adjust their dosage, but monitoring needs to be strengthened. Breastfeeding women should pause breastfeeding. The safety of medication for children has not yet been established. Mild to moderate renal insufficiency patients do not need to adjust the dosage, and severe patients should use it with caution.

6 Storage and administration requirements

Tablets should be swallowed whole and should not be broken or chewed. The original packaging should be stored in the dark below 25 ℃. Expired drugs should be disposed of through professional channels. Avoid consuming grapefruit and its products during medication.