Atorvastatin calcium tablets (Lipitor), as a potent lipid-lowering drug, significantly improve the lipid profile by inhibiting HMG CoA reductase, but attention should be paid to the risk of interaction with specific drugs. The following provides a detailed explanation of the effects and drug interactions.

1. Effect of action

(1) The daily dose of 10-80mg can reduce LDL-C by 39% -60%, and the effect is dose-dependent. The maximum efficacy occurs after 4 weeks of medication. Simultaneously reducing TG19% -37% in patients with mixed hyperlipidemia.

(2) Cardiovascular protection

Long term treatment reduces the risk of major cardiovascular events by 36% and stroke risk by 48%. The average volume of atherosclerotic plaque decreased by 0.79mm ³/year.

(3) Anti inflammatory effect

Significantly reduced CRP levels (median 37%), which is independent of lipid-lowering effects and particularly important for patients with acute coronary syndrome.

2 drug interactions

(4) When CYP3A4 inhibitors are used in combination with itraconazole and clarithromycin, the blood drug concentration increases by 7-9 times, increasing the risk of myopathy. If necessary, reduce to 10mg/day or switch to pravastatin.

(5) Inducing agent effect

Rifampicin and St. John's wort can reduce the AUC of atorvastatin by 80%, and the dosage needs to be adjusted to 40-80mg/day to maintain efficacy.

(6) Jifei Beiqi combination use

The risk of myopathy increases tenfold and is absolutely contraindicated. When combined with regular beta drugs, administration should be given at 12 hour intervals and CK values should be monitored.

(7) Oral contraceptive pills

The AUC of ethinylestradiol increased by 20%, and attention should be paid to the risk of breakthrough bleeding. It is recommended to use barrier contraception as an adjunct.

(8) Digoxin

When the steady-state concentration increases by 20%, it is necessary to monitor the blood concentration of digoxin when used in combination, especially in patients with renal dysfunction.