The contraindications of atorvastatin calcium tablets (Lipitor) involve specific population, food, and medication restrictions, and must be strictly followed to avoid serious adverse reactions. The following categories explain specific taboo content and precautions.

1 Taboo population

(1) Patients with active liver disease include unexplained persistent elevation of liver enzymes, acute liver failure, etc., which may exacerbate liver damage. Liver function should be tested before medication, and ALT/AST>3 times the upper limit of normal should be avoided.

(2) HMG CoA reductase inhibitors in pregnant women may cause fetal malformations. Women of childbearing age should use reliable contraception during medication and stop taking them immediately if pregnancy is detected.

(3) Medications can be secreted into breast milk during lactation, which may cause serious adverse reactions in infants. Medication should be suspended or breastfeeding should be stopped during lactation.

2 Forbidden Foods

(4) Daily intake of more than 1.2L of grapefruit juice and its products can increase blood drug concentration by 7 times and increase the risk of rhabdomyolysis. It is recommended to completely avoid consumption.

(5) A high-fat diet reduces drug absorption by 30%, and should be taken on an empty stomach at a fixed time (recommended before bedtime) to avoid taking it with a high-fat meal.

3 Restrictions

(6) Alcohol restriction increases the risk of muscle disease by 5 times for long-term alcoholics. It is recommended that men consume ≤ 25g of alcohol per day and women ≤ 15g.

(7) Exercise restriction: Intense exercise may induce muscle dissolution. During medication, avoid anaerobic exercise and control the intensity of aerobic exercise below a heart rate of 120 beats per minute.

(8) Combination therapy restrictions prohibit the use of gefitzil, cyclosporine, and other drugs. When used in combination with warfarin, INR values must be monitored weekly to stabilize.