Lometapai is an MTP inhibitor used to treat homozygous familial hypercholesterolemia. During medication, special attention should be paid to monitoring liver function, changes in fat metabolism, and nutrient supplementation to ensure safe and effective medication.

1. Liver toxicity monitoring

Lometapine may cause liver damage, and close monitoring of liver function is necessary during medication. It is recommended to check the transaminase level every 2 weeks during the initial stage of treatment, and then have regular follow-up. If the transaminase exceeds the normal upper limit by three times and persists, medication should be suspended or the dosage adjusted.

2. Fat metabolism and fat diarrhea

Due to the inhibition of fat absorption by Lometapine, patients may experience symptoms of fat diarrhea. Manifested as greasy, floating or difficult to flush stool. This is a common reaction in the mechanism of drug action, and it is necessary to inform the doctor in a timely manner.

Lack of 3 fat soluble vitamins

Medications can reduce the absorption of fat soluble vitamins (vitamins A, D, E, K). It is recommended to supplement these vitamins daily and increase the intake of relevant nutrients in the diet. When there is a serious lack, targeted supplementation should be carried out under the guidance of a doctor.

4 Gastrointestinal reactions

Common gastrointestinal reactions include nausea, vomiting, diarrhea, and abdominal pain. Suggest a low-fat diet, small meals, and avoid greasy foods. If symptoms persist or worsen, seek medical attention promptly.

5 Precautions for combined use with warfarin

When used in combination with warfarin, Lometapine may enhance anticoagulant effects. It is necessary to closely monitor the international normalized ratio (INR) and adjust the dose of warfarin based on the results to prevent bleeding risks.

6 Other important precautions

Effective contraception is necessary for women of childbearing age during medication use, and is prohibited during lactation. Medications should be stored at room temperature to avoid humid and high-temperature environments. When missed, there is no need to supplement the medication, and excessive data processing is limited. It is necessary to consult a doctor in a timely manner.