Common side effects of Pacritinib include diarrhea, nausea, and fatigue, which require targeted management measures. The following provides a detailed explanation from three aspects: symptom grading, treatment methods, and preventive measures.

Diarrhea management

(1) Mild diarrhea (grade 1-2): Immediately use antidiarrheal drugs such as loperamide, maintain electrolyte balance, and replenish fluids at least 2L daily.

(2) Severe diarrhea (grade 3): Suspend medication until recovery is ≤ grade 1, and subsequent treatment should reduce the dose (initially to 100mg/dose).

(3) Preventive measures: Avoid high fiber/dairy diets and continuously monitor bowel movements during treatment.

2 Nausea control

(1) Drug intervention: 5-HT3 receptor antagonists (such as ondansetron) are preferred, and dexamethasone can be used in combination for refractory nausea.

(2) Non pharmacological measures: Eat small meals frequently, avoid greasy foods, and drinking ginger tea between meals may have a relieving effect.

(3) Dose adjustment: For persistent grade 2 nausea, a reduction of 25% -50% should be considered.

3 Fatigue coping strategies

(1) Activity planning: Save energy and schedule important activities during the low drug concentration period (usually 4-6 hours after administration).

(2) Nutritional support: Ensure a daily protein intake of ≥ 1.2g/kg, and anemic patients need to supplement with iron and vitamin B12.

(3) Exclude the cause: Check thyroid function, hemoglobin and electrolyte levels, and correct abnormalities in a timely manner.

4 Other precautions

(1) Monitoring requirements: Complete blood cell count should be checked weekly for 4 weeks before treatment, and then rechecked monthly thereafter.

(2) Drug interactions: Avoid using QT interval prolonging drugs such as digoxin in combination, and monitor blood drug concentrations if necessary.

(3) Medical indication: Immediate medical attention is required if bloody diarrhea, persistent vomiting, or blurred consciousness occurs.