Cobenfy (xanomeline/trospium) is used for the treatment of schizophrenia. During medication, close attention should be paid to gastrointestinal tolerability, heart rate changes, and liver function to ensure safe medication.

I. Gastrointestinal Reactions

1. Common Manifestations

Nausea, vomiting, diarrhea, indigestion, and constipation are relatively common and mostly appear in the early stage of medication.

Some patients may experience gastrointestinal discomfort that affects eating and medication adherence.

2. Management Recommendations

It is recommended to take the medication with meals, eat small meals frequently, and avoid taking the medication on an empty stomach to prevent worsening nausea.

Maintain adequate hydration; patients with constipation may increase dietary fiber intake.

If symptoms persist or worsen (such as severe vomiting or dehydration), seek medical attention promptly and adjust the dose if necessary.

II. Heart Rate Changes

1. Manifestations to Watch For

Medication may cause increased heart rate or rhythm changes, with some patients experiencing palpitations and dizziness.

Patients with a history of cardiovascular disease are at relatively higher risk and require closer observation.

2. Monitoring and Response

Understand baseline heart rate and ECG status before medication, and monitor regularly during treatment.

Seek medical attention immediately if obvious palpitations, chest tightness, or pre-syncope occur.

Avoid concomitant use with other drugs that affect heart rate; consult a doctor before combined use.

III. Liver Function Monitoring

1. Necessity of Monitoring

Liver enzyme elevation may occur during medication, mostly without obvious symptoms.

Patients with a history of liver disease or those using potentially hepatotoxic drugs concomitantly require extra attention.

2. Monitoring Points

Recheck liver function regularly as directed by the doctor; promptly investigate if fatigue, loss of appetite, jaundice, or dark urine occurs.

If significant liver enzyme elevation is found, evaluate whether to adjust or discontinue the medication.