When Cobenfy (xanomeline/trospium) is used to treat schizophrenia, nausea, constipation, and indigestion are common gastrointestinal side effects. Most symptoms appear in the early stage of medication and can be effectively relieved by adjusting the medication method and diet.

I. Managing Nausea

1. Adjusting the Medication Method

It is recommended to take the medication with meals to avoid worsening nausea from taking it on an empty stomach.

The daily dose can be reasonably divided to reduce gastrointestinal irritation from a single dose.

2. Dietary and Lifestyle Adjustments

Eat small meals frequently and choose light, easily digestible foods; avoid greasy and spicy foods.

Avoid strong odor stimuli and avoid lying down immediately after meals.

Maintain adequate hydration to prevent dehydration caused by vomiting.

3. When to Seek Medical Attention

Seek medical attention promptly if vomiting persists, eating is impossible, or signs of dehydration appear; the doctor may adjust the dose if necessary.

II. Managing Constipation

1. Dietary Regulation

Increase dietary fiber intake and eat more vegetables, fruits, and whole grains.

Ensure adequate daily hydration to help soften stool.

2. Lifestyle Habits

Maintain regular bowel habits and engage in moderate activity to promote intestinal peristalsis.

Avoid prolonged sitting; activities such as walking can be performed within the body's tolerance.

3. Medication Assistance and Medical Attention

Use laxatives under the guidance of a doctor when necessary; do not abuse them long-term on your own.

Seek medical evaluation if constipation persists or is accompanied by obvious abdominal pain or bloating.

III. Managing Indigestion

1. Dietary Adjustments

Eat small meals frequently and chew food thoroughly to reduce the burden on the stomach.

Avoid overeating, alcohol, and irritating foods.

2. Coordination with Medication

Taking the medication with meals can reduce stomach discomfort.

Avoid concomitant use with drugs that may worsen gastrointestinal irritation; consult a doctor before combined use.

3. Observation and Management

Record symptom changes when upper abdominal discomfort, fullness, or acid reflux occurs.

Seek medical attention if symptoms persist or worsen to evaluate whether the treatment plan needs adjustment.

IV. Overall Management Points

1. Record Symptoms

Record the timing and severity of nausea, constipation, and indigestion to facilitate medication adjustment by the doctor.

2. Adjust According to Medical Advice

Do not stop the medication or increase or decrease the dose on your own; adjustments should be decided by the doctor.

3. Seek Medical Attention Promptly

Seek medical attention as soon as possible if severe vomiting, dehydration, severe abdominal pain, or long-term unresolved constipation occurs.