To ensure efficacy and safety, the administration method, dosage adjustment, and management of missed doses of Crizotinib should follow the following guidelines.

1. Method and timing of administration

1.1 Fasting or with meals: It can be taken with food or on an empty stomach, but it should be avoided to eat with high-fat meals, as a high-fat diet may increase drug absorption and affect blood drug concentration stability. It is recommended to take medication at a fixed time every day.

1.2 Whole capsule ingestion: The capsule should be taken whole with warm water and should not be chewed, crushed, or opened.

2. Principle of dose adjustment

2.1 Initial dose: The recommended daily dose is 250mg, twice a day (with an interval of approximately 12 hours).

2.2 Reduction standard: When adverse reactions occur, the reduction can be carried out in the following steps:

First dose reduction: 200mg, twice daily;

Secondary reduction: 250mg, once daily;

If intolerance persists, the medication needs to be permanently discontinued.

2.3 Combination medication adjustment: When used in combination with strong CYP3A4 inhibitors, the dosage may need to be reduced; The combination with strong CYP3A4 inducers should be avoided.

3. Handling of missed services

3.1 If missed for less than 6 hours: Take it immediately and take it on time next time.

3.2 If missed for more than 6 hours: skip this dose and take the medication according to the original plan next time. Do not double the dosage.

3.3 Post vomiting treatment: If vomiting occurs after taking medication, there is no need to take it again. You can take it on time next time.

4. Precautions

4.1 Liver and kidney function monitoring: During medication, regular checks of liver enzymes and kidney function are required, and dosage adjustments should be made in case of abnormalities.

4.2 Avoid Grapefruits: During medication, it is not advisable to consume grapefruit or drink grapefruit juice to avoid affecting drug metabolism.