Nausea, diarrhea, and edema are common side effects during treatment with crizotinib. Scientific management helps improve the quality of life and ensure continuity of treatment.

1. Nausea management

1.1 Medication method: It can be taken together with food to reduce stomach irritation and avoid taking medication on an empty stomach.

1.2 Diet adjustment: choose light and digestible food, such as rice porridge and noodles; Avoid greasy, spicy, or overly sweet foods.

1.3 serving of individual dishes: eat less and more meals to reduce the burden on the stomach.

1.4 antiemetic preparation: If nausea is obvious, antiemetic drugs such as ondansetron can be used under the guidance of a doctor.

2. Diarrhea management

2.1 Fluid replacement to prevent dehydration: Drink plenty of water or take oral rehydration salts to replenish fluids and electrolytes.

2.2 Dietary choices: Avoid high fiber, dairy products, and gas producing foods (such as beans), and choose easily digestible foods such as bananas and white rice.

2.3 Drug intervention: When diarrhea is severe, loperamide (Yimengting) can be used according to medical advice to control symptoms.

2.4 Perianal care: Rinse with warm water after use, apply buttock cream to prevent skin damage.

3. Edema management

3.1 Low salt diet: reduce the intake of salt and pickled food, which helps to reduce water and sodium retention.

3.2 Elevating the affected limb: Elevate both lower limbs during rest to promote venous return and reduce lower limb edema.

3.3 Loose fitting: Choose loose fitting shoes and socks to avoid pressure affecting circulation.

3.4 Monitoring weight: Weigh yourself every morning, and if there is a significant increase in weight in the short term, inform the doctor for evaluation.

4. Medical indications

If severe diarrhea (more than 6 times a day), persistent vomiting, inability to eat, sudden difficulty breathing, or significant weight gain occurs, immediate medical attention should be sought, and the doctor should evaluate whether to adjust the dose of crizotinib or provide symptomatic treatment.