Mitotane is an oral cytotoxic drug for adrenal cells, and its mechanism of action is not fully understood. It mainly exerts pharmacological effects by regulating the peripheral metabolism of steroids and directly inhibiting the adrenal cortex.

1、 Drug name:

1. Product Name: LYSODREN

2. Common name: Mitotane

2、 Indications:

Used to treat functional or non functional adrenal cortical carcinoma (ACC) that cannot be surgically removed.

3、 Specifications and characteristics:

500mg white, round.

4、 Main components:

Active ingredient: Mitotan

5、 Usage and dosage:

1. Initial dose: 2000mg to 6000mg per day, taken orally in three or four doses with meals.

2. Dose adjustment: Gradually increase the dose based on patient tolerance and clinical response to achieve a plasma concentration of 14 to 20mg/L.

3. The target plasma concentration is usually achieved within 3 to 5 months, followed by regular monitoring (such as monthly).

6、 Dose adjustment:

Adjust the dosage based on the plasma concentration and toxicity of mitoxan. If the plasma concentration exceeds 20mg/L and is non-toxic, consider reducing the dose by 50% to 75%.

7、 Medication precautions:

1. Before and after meals: Take with meals, especially high-fat foods can enhance absorption.

2. Missed dose: If missed, skip this dose and take the next dose according to the original plan. Do not double the dose.

3. Vomiting: If vomiting occurs after taking, take the next dose according to the original plan and do not double the dose.

8、 Medication for special populations:

1. Pregnant and lactating women: May be harmful to the fetus, lactating women should avoid breastfeeding.

2. Women with reproductive potential: It is recommended to use effective non hormonal contraceptive methods.

3. Children and adolescents: effectiveness has not been established and may affect neuropsychological development.

4. Elderly people: Dosage selection should be cautious, usually starting with low doses.

5. Patients with liver and kidney dysfunction: Patients with mild to moderate liver and kidney dysfunction need to frequently monitor plasma concentrations and adjust doses. It is not recommended for patients with severe liver and kidney dysfunction.

9、 Adverse reactions:

1. Common adverse reactions include loss of appetite, upper abdominal discomfort, nausea, vomiting, diarrhea, depression, dizziness, vertigo, rash, hypercholesterolemia, hypertriglyceridemia, hypothyroidism, and reduced free testosterone in male blood.

2. Serious adverse reactions include: adrenal insufficiency and adrenal crisis, central nervous system toxicity, ovarian cysts, hepatotoxicity, hematological toxicity, prolonged bleeding time, embryo fetal toxicity, etc.

10、 Contraindications:

No specific contraindications are listed.

11、 Drug interactions:

Avoid simultaneous use with spironolactone, certain CYP3A substrates, hormonal contraceptives, warfarin, and other medications as they may reduce their effectiveness or increase the toxicity of mitoxanes.

12、 Storage method:

1. Stored at 25 ° C (77 ° F), with a permissible range of 15 ° C to 30 ° C (59 ° F to 86 ° F).

2. Mitotan is a dangerous drug that requires special handling and disposal procedures to be followed.

Mitotaneinformation