Xenleta is a systemic pleuromutilin antibiotic that exerts antibacterial effects by inhibiting bacterial protein synthesis.

1、 Drug name

Common name: Lefamulin

Product Name: Xenleta

2、 Indications

Used to treat community-acquired bacterial pneumonia (CABP) in adults, caused by susceptible microorganisms including Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydia pneumoniae.

3、 Specifications and characteristics

Tablets: Blue oval shaped film coated tablets with black "LEF600" printed on one side, each containing 600mg of Levofloxacin.

4、 Main components

The active ingredient is Levofloxacin acetate, which belongs to the class of Truncated Pleurotus antibiotics.

5、 Usage and dosage

Tablets: 600mg orally every 12 hours, with a treatment course of 5 days.

6、 Dose adjustment

Patients with liver dysfunction:

Tablets: Not recommended for patients with moderate or severe liver injury.

7、 Medication precautions

Medication time: Tablets should be taken 1 hour before meals or 2 hours after meals.

Usage: Swallow the whole tablet, use 6-8 ounces of water, do not crush or separate.

Omission treatment: If it is more than 8 hours before the next dose, it can be taken again, otherwise the dose will be skipped.

Vomiting treatment: If vomiting occurs, consult a doctor to see if additional medication is needed.

8、 Medication for special populations

Pregnant women: May cause fetal damage, confirm pregnancy status before medication.

Breastfeeding period: During treatment and within 2 days after the last dose, breast milk should be pumped out and discarded.

Elderly: No need to adjust dosage.

Children: The safety and efficacy of patients under 18 years old have not been established.

9、 Adverse reactions

Common reactions of tablets: diarrhea, nausea, vomiting, and elevated liver enzymes.

10、 Contraindications

Individuals who are allergic to Lefamolin, Truncated Pleurotus ostreatus, or any component of Xenleta.

Simultaneously using tablets and CYP3A substrates that prolong QT interval.

11、 Drug interactions

Avoid co administered medications:

Strong or moderate CYP3A inducers or P-gp inducers (unless the benefits outweigh the risks).

Tablets with strong CYP3A inhibitors or P-gp inhibitors.

Medications that prolong the QT interval, such as antiarrhythmic drugs and antipsychotic drugs.

12、 Storage method

Injection: Refrigerate at 2 ° C-8 ° C and not freeze; After dilution, it can be stored at room temperature for 24 hours and refrigerated for 48 hours.

Tablets: Store at room temperature between 20 ° C and 25 ° C.

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