The dosage of Capmatinib needs to be adjusted according to the specific situation of the patient, and is mainly suitable for adult patients with metastatic non-small cell lung cancer with MET exon 14 jump mutation. The standard dose is taken orally twice a day, and the whole tablet needs to be swallowed. Common adverse reactions include peripheral edema, nausea, etc. Regular monitoring of liver function is required.

1. Conventional dosing regimen

(1) Standard dose: 400 milligrams each time, twice a day (with an interval of about 12 hours), can be taken with meals or on an empty stomach.

(2) Dosage form specification: Usually 200 milligrams per tablet, 2 tablets need to be taken each time to meet the single dose requirement.

Adjustment for Special Groups 2

(1) Liver dysfunction: Patients with moderate impairment (Child Pugh B grade) should reduce their dosage to 200 milligrams twice a day; Severe damage (Child Pugh C grade) is prohibited.

(2) Renal insufficiency: mild to moderate damage does not require adjustment; Data on end-stage renal disease or dialysis patients is limited and should be used with caution.

3 Principles of Dose Adjustment

(1) Reduction level: The first dose is reduced to 300 milligrams twice daily, and the second dose is reduced to 200 milligrams twice daily. If the patient still cannot tolerate it, the medication will be permanently discontinued.

(2) Adjustment indication: If there are ≥ grade 3 adverse reactions, symptomatic bradycardia, interstitial lung disease, etc., medication should be suspended.

4 Medication precautions

(1) Omission treatment: If it is less than 4 hours before the next administration, skip and do not supplement or double the dose.

(2) Drug interactions: Avoid co administration with strong CYP3A inducers, and use with proton pump inhibitors with a 2-hour interval.