Tamiflu, as a neuraminidase inhibitor, has significant therapeutic effects on influenza A and B viruses, shortening the course of the disease and reducing the risk of complications. The discontinuation plan should be determined based on the treatment purpose (treatment or prevention) and the individual situation of the patient, and special attention should be paid to the safety of medication and the timing of discontinuation for special populations.

1. Therapeutic effect

(1) Shortened course of illness

Clinical studies have shown that medication taken within 48 hours of symptom onset can shorten the course of illness by about 1-2 days, with more significant benefits for critically ill and high-risk populations, and a 40% -60% reduction in hospitalization risk.

(2) Symptom relief

It can significantly alleviate flu symptoms such as fever, cough, and muscle pain, and the symptom improvement rate within 24 hours is 30% -50% higher than that of the placebo group.

(3) Preventive effect

The effective rate of prevention after exposure can reach 70% -90%, and the prevention during the community epidemic period can reduce the incidence rate by more than 50%. The protective effect is equivalent to that of vaccination.

2. Precautions for discontinuation of medication

(1) Therapeutic medication

The standard course of treatment is 5 days, and even if symptoms are relieved early, the entire course of treatment should be completed to avoid virus replication rebound or drug resistance.

(2) Preventive medication

Prevention after close contact should last for 10 days, and prevention during the community epidemic period can last up to 6 weeks. After stopping medication, protective measures should still be taken.

(3) Discontinue medication for special populations

Patients with renal insufficiency need to adjust their course of treatment based on creatinine clearance rate; Pregnant women who need to discontinue medication should assess fetal risk; Children should avoid sudden discontinuation of medication.

3. Monitoring after discontinuation of medication

(1) Symptom recurrence

If recurrent fever or worsening respiratory symptoms occur after discontinuation of medication, virus resistance or secondary infection should be considered, and timely medical follow-up should be sought.

(2) Adverse reaction tracking

Pay attention to the delayed onset of psychiatric symptoms such as hallucinations and delirium, especially in children and adolescents within 1-2 weeks after discontinuing medication.

(3) Immune function recovery

HIV infected individuals may develop immune reconstitution syndrome after discontinuing medication, and potential infection symptoms need to be monitored.