Tebipenem granules have shown good clinical efficacy in the treatment of respiratory tract infections in children. Its discontinuation should be gradually carried out according to the infection control situation, and attention should be paid to allergic reactions and intestinal microbiota recovery. The following provides specific explanations from two aspects: evaluation of treatment efficacy and precautions for discontinuing medication.

1. Evaluation of treatment efficacy

(1) Bacterial clearance rate: The bacterial clearance rate against common pathogens such as Streptococcus pneumoniae and Haemophilus influenzae is over 90%, especially effective against beta lactase producing strains.

(2) Clinical efficacy rate: The clinical efficacy rate for treating otitis media and pneumonia in children exceeds 85%, and the symptom relief time is usually 3-5 days.

(3) Drug resistance management: As a carbapenem antibiotic, it is recommended to use drug sensitivity testing to guide medication and avoid empirical long-term use.

2. Precautions for discontinuation of medication

(1) Course control: The standard course of treatment is 5-10 days, and the entire course of treatment should be completed even if symptoms are relieved early to prevent recurrence and drug resistance.

(2) Gradual discontinuation of medication: For severely infected patients, it is recommended to continue taking medication for 48-72 hours after the symptoms have disappeared, and sudden discontinuation of medication is not allowed.

(3) Allergy monitoring: After stopping the medication, it is still necessary to observe for 72 hours whether there is a delayed type allergic reaction, such as rash or difficulty breathing.

(4) Intestinal recovery: It is recommended to continue using probiotics for 1-2 weeks after discontinuing medication to prevent antibiotic associated diarrhea.

(5) Efficacy evaluation: After stopping the medication for 3 days, a follow-up visit is required to confirm complete control of the infection, and microbiological examination may be necessary.