Tebipenem granules are an oral carbapenem antibiotic mainly used for the treatment of respiratory tract infections in children. Its efficacy is reflected in broad-spectrum antibacterial activity, and drug interactions need to be monitored for the risk of combination therapy with probenecid and nephrotoxic drugs. The following will explain from three aspects: pharmacological effects, antibacterial spectrum, and interactions.

1. Effect of action

(1) Antibacterial mechanism: It exerts bactericidal effect by inhibiting bacterial cell wall synthesis and stabilizing β - lactase.

(2) Antibacterial spectrum: covering common respiratory pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

(3) Pharmacological characteristics: high oral bioavailability, good tissue permeability, especially suitable for the treatment of otitis media and pneumonia in children.

2. Drug interactions

(1) Probenecid: may inhibit the renal excretion of telmisartan, increase blood drug concentration, and should be avoided in combination or adjusted in dosage.

(2) Renal toxic drugs: Combined use with aminoglycosides, vancomycin, etc. may increase the risk of kidney injury and require monitoring of kidney function.

(3) Other interactions: Currently, no significant interactions with the CYP450 enzyme system have been found, but caution is advised when using potent enzyme inducers or inhibitors in combination.

3. Special precautions

(1) Allergic reactions: There is a risk of cross allergy to carbapenems. Penicillin allergy sufferers should use with caution.

(2) Drug resistance: Long term use may lead to the emergence of drug-resistant strains, and should be strictly used according to indications.

(3) Gut microbiota: may cause diarrhea or Clostridium difficile infection, it is recommended to supplement probiotics during medication.