As an acute treatment drug for migraine, Rizatariptan often has mild side effects such as dizziness and fatigue, which can be relieved on their own. However, serious cardiovascular or allergic reactions should be noted. The following provides a detailed explanation from three aspects: common side effects, serious side effects, and mitigation measures.

1. Common side effects and alleviation

(1) Neurological response

The incidence of dizziness or drowsiness is about 15%. It is recommended to lie down and rest after taking medication, avoid driving or operating machinery, and usually relieve on its own within 2-4 hours.

(2) Gastrointestinal discomfort

The incidence of nausea is up to 10%, which can be relieved by drinking ginger tea in small sips or taking domperidone. Avoid taking medication on an empty stomach to reduce irritation.

(3) Feeling abnormal

Limb numbness or tingling sensation accounts for about 8%. Local massage can be used to promote blood circulation. If it persists for more than 6 hours, medical attention should be sought.

2. Serious side effects to be cautious of

(1) Cardiovascular events

Sudden chest pain and palpitations require immediate discontinuation of medication and medical attention, which may indicate coronary artery spasm, especially in individuals with a history of cardiovascular disease who are at higher risk.

(2) Allergic reactions

When urticaria and laryngeal edema occur and cause allergic reactions, adrenaline should be used immediately and emergency treatment should be sought.

(3) Cerebrovascular abnormalities

Sudden severe headache accompanied by changes in consciousness may indicate intracranial hemorrhage and require urgent CT examination to rule it out.

3. Precautions for special populations

(1) Liver and kidney dysfunction

The dosage for patients with moderate liver damage is halved, and severe renal failure (eGFR<30) is contraindicated as it may exacerbate drug accumulation.

(2) Medication during pregnancy

Avoid use during pregnancy, animal experiments have shown embryotoxicity, and strict monitoring of fetal condition is necessary when use is necessary.

(3) Drug interactions

Do not use in combination with MAOI drugs, with an interval of at least 14 days, otherwise it may cause serotonin syndrome.