The discontinuation of omega-3 fatty acids (Lotriga) should be gradually reduced or directly discontinued according to individual circumstances, and the specific method should follow the doctor's advice to avoid sudden cessation of medication that may cause lipid rebound or other discomfort reactions.

1. Hypertriglyceridemia

Omega-3 fatty acids are suitable as adjuvant therapy for severe hypertriglyceridemia (≥ 500mg/dL) in adults, which can effectively reduce triglyceride levels and lower the risk of pancreatitis. Its mechanism of action is to inhibit the synthesis of very low-density lipoprotein in the liver and promote fatty acid oxidation.

2. Prevention of cardiovascular diseases

(1) Used for diagnosing coronary heart disease patients, reducing the risk of cardiovascular event recurrence, especially for residual risk management of poorly controlled statins.

(2) It can protect blood vessels of patients with hypertension and atherosclerosis, improve endothelial function, and delay the progress of plaque.

3 Conventional Discontinuation Methods

(1) For long-term users, it is recommended to gradually reduce the dosage under the guidance of a doctor, for example, starting with a daily dose reduction of 25% -50%, observing for 1-2 weeks without any abnormalities before completely stopping the medication.

(2) Short term users (such as 1-3 months) or on-demand users can usually discontinue medication directly without the need for a special reduction process.

4. Handling of Special Situations

(1) If used for severe hypertriglyceridemia, close monitoring of blood lipid levels is necessary after discontinuation to prevent indicator rebound.

(2) When combining lipid-lowering drugs (such as statins), it is necessary to evaluate the overall treatment plan and adjust it to avoid the impact of discontinuation of a single drug on efficacy.

5 Precautions

(1) After discontinuing medication, maintain a balanced diet and moderate intake of foods rich in omega-3 (such as deep-sea fish) to maintain stable blood lipids.

(2) When possible discomfort symptoms such as fatigue and dry skin appear, it is recommended to have a follow-up evaluation to determine whether medication needs to be restored or the dosage adjusted.

6 Follow up recommendations

(1) After stopping the medication, the blood lipid profile should be rechecked one month to confirm the control of indicators.

(2) Individuals with cardiovascular high-risk factors need to be continuously monitored and medication treatment may be restarted if necessary.