The usage and dosage of Omega-3 fatty acids (Lotriga) should be adjusted according to the indications. Special populations should pay attention to pregnancy, lactation, and liver and kidney function abnormalities when taking medication. The specific medication plan should strictly follow the doctor's advice.

1. Usage and dosage

(1) Hypertriglyceridemia: The recommended daily dose for adults is 2-4 grams, taken with meals in divided doses, with a maximum daily dose not exceeding 4 grams. Blood lipid levels should be monitored regularly.

(2) Cardiovascular disease prevention: usually 1-2 grams per day, can be used in combination with statins, and the specific dosage needs to be adjusted according to the patient's cardiovascular risk stratification and individualization.

2. Medication for special populations

(1) Pregnancy: Animal studies have shown that high doses may affect fetal development. Pregnant women need to weigh the pros and cons and only use the lowest effective dose when it is clearly necessary.

(2) Breastfeeding period: A small amount of omega-3 can be secreted into breast milk. Breastfeeding women are advised to consult a doctor and suspend breastfeeding or adjust medication plans if necessary.

(3) Children: Insufficient safety and efficacy data for children under 12 years old, not recommended for routine use; Children aged 12 and above must strictly follow the pediatric dosage adjustment.

(4) Elderly people: No regular dose adjustment is required, but those with multiple diseases or taking other medications should be alert to interactions and closely monitor adverse reactions.

3. Abnormal liver and kidney function

(1) Liver dysfunction: Mild to moderate abnormalities do not require dose adjustment, while severe liver dysfunction patients should reduce dosage by 50% and monitor changes in liver enzymes.

(2) Renal insufficiency: Patients with creatinine clearance rate of 30-60mL/min do not need to adjust, while patients with end-stage renal disease need to reduce the dose to below 1g per day.

4 Precautions

(1) People who are allergic to fish or shellfish may experience cross allergic reactions, and close observation is necessary for the first use.

(2) Combined use with anticoagulant drugs may increase the risk of bleeding, and coagulation function needs to be monitored and anticoagulant dosage adjusted if necessary.