During the treatment of Repotrectinib, special attention should be paid to dietary taboos, including the prohibition of grapefruit fruits, high-fat diet restrictions, and alcohol avoidance. These measures can effectively reduce the risk of adverse drug reactions.

1. Effect of action

(1) Clinical efficacy

For NTRK positive solid tumor patients aged 12 and above, it can effectively inhibit tumor progression, especially for locally advanced or metastatic cases with clear therapeutic effects.

(2) Pharmacodynamic characteristics

After taking on an empty stomach, the peak blood drug value is reached 2-3 hours later, with a bioavailability of 45.7% and a half-life of about 40.3 hours. The duration of the drug effect is relatively long.

2 Absolutely Forbidden Foods

(1) Citrus fruits

It is prohibited to consume grapefruit, grapefruit and their products, as these fruits significantly inhibit CYP3A4 metabolic enzymes, leading to abnormally high blood concentrations of riptinib and increasing the risk of side effects.

3 Restrictive Diets

(1) High-fat food

Although studies have shown that high-fat diets (800-1000 calories) have no significant effect on pharmacokinetics, long-term high-fat diets may increase the metabolic burden on the liver, and it is recommended to maintain a balanced diet.

(2) Alcoholic beverages

It is necessary to strictly limit alcohol intake, as alcohol may exacerbate central nervous system adverse reactions such as dizziness and ataxia caused by medication.

4 Dietary Time Suggestions

(1) Timing of medication

It is recommended to take the medication on an empty stomach at a fixed time (1 hour before or 2 hours after meals) to ensure stable absorption and a bioavailability of 45.7%.

(2) Drinking water requirements

When taking medication, it is recommended to drink 200ml of warm water and avoid taking it together with drinks that may affect the efficacy, such as grape juice and orange juice.

5 Special Nutrient Supplements

(1) Vitamin K control

During long-term medication, it is necessary to monitor coagulation function. Sudden increase in vitamin K intake may affect anticoagulant efficacy.

(2) Calcium supplementation

It is recommended to regularly check blood calcium levels and supplement them under the guidance of a doctor if necessary to prevent possible hypocalcemia caused by medication.