As a KRASG12C inhibitor, common side effects such as nausea, vomiting, and fatigue of Adagrasib can be effectively managed through medication adjustments, lifestyle interventions, and symptomatic treatment. The following provides specific recommendations from three aspects: preventive measures, symptom relief, and medical indications.

1. Nausea management

(1) Preventive measures: Eat light foods in small portions and avoid high-fat/spicy foods; Avoid drinking too much water for one hour before and after taking medication.

(2) Medication intervention: Use antiemetic drugs such as ondansetron according to medical advice, and adjust the medication time of adagracilib until bedtime in severe cases.

2 Vomit control

(1) Principle of fluid replacement: Drink electrolyte solution in small amounts multiple times after vomiting, 50-100ml each time, with an interval of 10 minutes.

(2) Warning symptoms: If vomiting persists for more than 24 hours, vomiting blood or coffee like substances, seek medical attention immediately. Be alert to signs of dehydration such as decreased urine output.

3 Fatigue coping strategies

(1) Schedule adjustment: Adopt intermittent activity mode, with a 10 minute break every 30 minutes of activity; Prioritize completing important tasks.

(2) Nutritional support: Increase the intake of high-quality protein, supplement with vitamin B when necessary, and avoid caffeine intake in the afternoon that affects nighttime sleep.

4 medical indications

(1) Nausea and vomiting accompanied by a weight loss of more than 5% and dizziness while standing indicate the need for medical intervention.

(2) Fatigue combined with difficulty breathing, palpitations, or blurred consciousness may indicate anemia or cardiac toxicity and require urgent evaluation.

Note: All symptom management plans must be confirmed by the attending physician to avoid self medication with antiemetic drugs or stimulants. It is recommended to keep a symptom diary every week during the treatment period for dose adjustment.